Description:
Salirasib is a salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast.
Molecular Formula:
C22H30O2S
Canonical SMILES:
CC(=CCCC(=CCCC(=CCSC1=CC=CC=C1C(=O)O)C)C)C
InChI:
InChI=1S/C22H30O2S/c1-17(2)9-7-10-18(3)11-8-12-19(4)15-16-25-21-14-6-5-13-20(21)22(23)24/h5-6,9,11,13-15H,7-8,10,12,16H2,1-4H3,(H,23,24)/b18-11+,19-15+
InChIKey:
WUILNKCFCLNXOK-CFBAGHHKSA-N
Synonyms:
Salirasib; Farnesylthiosalicylic acid; S-Farnesylthiosalicylic acid; FTS. Más detalles se encuentran
aquí
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